Metabolomic Analysis of Leishmania

Grant number: 1006023 | Funding period: 2011 - 2013

Completed

Abstract

Leishmania are single-celled parasites that target a major class of immune cell, affecting millions and killing thousands of people worldwide. We have developed new approaches for investigating how these parasites survive in the immune cells, and why different species of Leishmania cause markedly different pathologies. This information will be used to identify and validate new drug targets in these parasites.

Related publications (4)

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Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages

T Naderer, J Heng, EC Saunders, J Kloehn, TW Rupasinghe, TJ Brown, MJ McConville

2015-01-01

Leishmania parasites replicate within the phagolysosome compartment of mammalian macrophages. Although Leishmania depend on sugars..

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Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

EC Saunders, WW Ng, J Kloehn, JM Chambers, M Ng, MJ McConville

2014-01-01

Leishmania parasites alternate between extracellular promastigote stages in the insect vector and an obligate intracellular amasti..

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Leishmania major Methionine Sulfoxide Reductase A Is Required for Resistance to Oxidative Stress and Efficient Replication in Macrophages

FM Sansom, L Tang, JE Ralton, EC Saunders, T Naderer, MJ McConville

2013-02-20

Leishmania are protozoan parasites that proliferate within the phagolysome of mammalian macrophages. While a number of anti-oxidan..

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PyMS: A Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools

S O'Callaghan, DP De Souza, A Isaac, Q Wang, L Hodkinson, M Olshansky, T Erwin, B Appelbe, DL Tull, U Roessner, A Bacic, MJ McConville, VA Likić

2012-05-30

Background: Gas chromatography-mass spectrometry (GC-MS) is a technique frequently used in targeted and non-targeted measurements ..

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